Active Studies

HPTN 085: Evaluating the Safety and Efficacy of the VRC01 Antibody in Reducing Acquisition of HIV-1 Infection

RELEVANCE: Preliminary data have shown antibodies to be a potential efficacious intervention in preventing HIV-1 infection.

DESCRIPTION: This study will evaluate the safety, tolerability, and efficacy of the VRC01 antibody in preventing HIV-1 infection in healthy adults at high risk of HIV infection. Participants will be men who have sex with men (MSM) and transgender people in the U.S., Peru and Brazil. An equal number of study participants will be randomized to receive VRC01 mAb by IV infusion at a dose of 10 mg/kg or 30 mg/kg every 8 weeks, or to receive control infusions every 8 weeks. All participants will receive the VRC01 antibody or placebo by intravenous infusion at Weeks 0 (study entry), 8, 16, 24, 32, 40, 48, 56, 64, and 72. For 3 days following each infusion, participants will be asked to record and report any symptoms to study researchers. In addition to the infusion visits, participants will attend study visits at Weeks 4, 8 + 5 days, 12, 20, 28, 36, 44, 52, 60, 68, 76, 80, 84, 88, and 92. All study visits will include blood collection and HIV testing and counseling. Select study visits will include a medical history review, physical exam, urine collection, pregnancy testing for participants capable of becoming pregnant, risk reduction counseling, and an interview/questionnaire.

STATUS: Currently Enrolling

Phase II Randomized Trial of Ibudilast For Methamphetamine Dependence

RELEVANCE: Despite numerous clinical trials, no medication has been approved to treat methamphetamine (MA) dependence. As a result, novel approaches to medication development for MA dependence, including linked medication development, where work in early safety trials can be used to inform the importance of continued (or not) assessment of novel or combination pharmacotherapies, is needed.

DESCRIPTION: Following up on the Phase I safety trial, the objective of this study is to test the safety and potential efficacy of ibudilast to treat methamphetamine dependence. The study hypotheses are that ibudilast will reduce methamphetamine use and increase treatment retention more than placebo among patients seeking treatment for methamphetamine dependence. As HIV infection is a common complication of methamphetamine dependence, half of the participants will be HIV positive and the study will assess whether ibudilast also improves HIV related outcomes (e.g. medication adherence, CD4 count, risk behaviors).

STATUS: Currently enrolling treatment seeking, methamphetamine-dependent persons. For more information, call us toll free at 866-449-UCLA (8252) or email uclavsc@mednet.ucla.edu.

Using Social Media with Latino Men Who Have Sex with Men for HIV Testing and Linkage

RELEVANCE: In Los Angeles County Latinos comprise approximately 50% of all annually reported HIV infections, and Latino men who have sex with men (MSM) make up 85% of all HIV infections among Latinos. Identifying innovative ways of engaging Latino MSM in HIV testing, medical care, and prevention services has the potential to decrease HIV transmission among this population and improve health outcomes of those living with HIV.

DESCRIPTION: We propose to develop a culturally-tailored intervention to increase HIV testing and linkage to HIV medical care and prevention services among Latino MSM unaware of their HIV status. The intervention will consist of three interconnected and complementary components: 1) the use of social media, 2) the use of conditional cash transfers, and 3) linkage coordination to HIV medical care and/or prevention services. Social networking sites (SNS) with geo-based location services will be used to recruit high-risk Latino MSM. We hypothesize that our culturally-tailored social media program will result in identifying higher rates of HIV-positive Latino MSM, newly-identified HIV-positive Latino MSM accessing HIV medical care, and HIV-positive and high-risk HIV-negative Latino MSM accessing HIV prevention services compared to the local standard of care.

STATUS: This study has completed enrollment and data analysis is underway. For information on the results of this study, please contact the Principal Investigator, Dr. Ron Brooks, at rbrooks1@ucla.edu or by phone at 310-794-0619 ext. 226.

MSM and Substances Cohort at UCLA Linking Infections Noting Effects (MASCULINE), better known as the M Study

RELEVANCE: Stimulant use, especially among men who have sex with men (MSM) in Los Angeles County (LAC) is common.  Stimulant drug use, particularly methamphetamine use, is a significant factor in the progression of HIV and STI among MSM in LAC.  Non-white MSM are at greatest risk of HIV infection in the United States.  Analyses of drug use are needed among diverse samples of MSM in order to understand the impact of drug use on the HIV epidemic over time and to address the effect of long-term drug use patterns on uptake and adherence to treatment and prevention of the disease.

DESCRIPTION: The goal of this project is to assemble a cohort of minority men who have sex with men (MMSM) who actively use substances and engage transmission risks. This will facilitate studies on interactions between substance use and HIV progression and/or transmission. This important cohort of MMSM will characterize: (i) effects substance use on risk behaviors, and network dynamics in exposed and infected MMSM on acquisition of HIV and other sexually transmitted infections (STIs: gonorrhea, Chlamydia, syphilis, Hepatitis C (HCV)); and (ii) the extent to which substance use in MMSM facilitates behaviors that transmit HIV compared to non-drug using MMSM.

STATUS: Currently enrolling at 2 sites. For more information, visit the study website at http://www.theMstudy.org.

Combating Craving with Contingency Management: Neuroplasticity and Methamphetamine Abuse in South Africa

RELEVANCE: Methamphetamine (MA) addiction is a global health problem with high prevalence and great social and health costs in the United States and in the Republic of South Africa and there is a strong need for development and implementation of effective MA treatment approaches.

DESCRIPTION: This study will enroll treatment-seeking, MA-dependent individuals into an 8-week contingency management (CM) program. At the beginning and end of the program, participants will participate in MRI scans while performing a working memory task and will complete a battery of select neurocognitive and psychological assays to address two specific aims: (1) to determine whether changes in neural function within frontostriatal circuitry (neural pathways that connect frontal lobe regions with the basal ganglia (striatum)) that mediate motor, cognitive, and behavioral functions within the brain from baseline to end of the 8-week CM program are associated with parallel changes in measures of cognitive control and impulsivity and with MA abstinence outcomes; (2) to determine whether structural changes in frontostriatal circuitry over the 8-week CM intervention correspond with neurocognitive, psychological and MA abstinence measures. Findings from this study will describe associations between functional and structural indices of brain areas that support working memory, cognitive control/inhibition; performance on select neurocognitive and psychological assessments; and associations between these with MA abstinence outcomes. Study activities and the neuroscience data generated will provide preliminary data for a larger, adequately powered study that will test ways to optimize behavioral therapies for treating stimulant use disorder.

STATUS: Currently enrolling at the University of Cape Town.

Phase II Randomized, Double-Blind Controlled Trial of HORIZANT® for Alcohol Use Disorder

RELEVANCE: Alcohol Use Disorder (AUD) affects 18 million Americans, and is linked to 80,000 deaths a year, presenting a staggering $224 billion dollar economic loss to society. Yet, there are only four medications approved by the FDA to treat AUD.

DESCRIPTION: The primary objective of this study is to compare the efficacy of HORIZANT® with a placebo on individuals with AUD. The secondary objectives are to assess other treatment benefits such as reduction in alcohol consumption, reduction in cravings of alcohol, mood, sleep quality, smoking quantity and frequency, and safety.

STATUS: Enrollment closed.

59 thoughts on “Active Studies

  1. Pingback: blue ofica

  2. Pingback: alkaline water machine

  3. Pingback: cheats hay day

  4. Pingback: alkaline water

  5. Pingback: alkaline water

  6. Pingback: kangen

  7. Pingback: best minecraft seeds

  8. Pingback: enagic kangen water

  9. Pingback: buy cannabinoids uk

  10. Pingback: buy bk-2c-b pellets uk

  11. Pingback: methiopropamine uk

  12. Pingback: water ionizer

  13. Pingback: water ionizer

  14. Pingback: alkaline water machine

  15. Pingback: kangen alkaline water

  16. Pingback: Peter Smith

  17. Pingback: alkaline water

  18. Pingback: dwoehfbgydbcnkehtyfgdvfdhf

  19. Pingback: alkaline water

  20. Pingback: prediksi bola

  21. Pingback: discover this info here

  22. Pingback: Blue Coaster

  23. Pingback: watch free movies online

  24. Pingback: streaming movies

  25. Pingback: water ionizer

  26. Pingback: kangen water

  27. Pingback: vpn service

  28. Pingback: online casinos

  29. Pingback: uk online casinos

  30. Pingback: Clothes off blowage

  31. Pingback: tvpackages.net

  32. Pingback: payday loans with no checking account

  33. Pingback: DIRECTV Satellite Television

  34. Pingback: 3gp mobile porn

  35. Pingback: lan penge

  36. Pingback: alkaline water benefits

  37. Pingback: bottled alkaline water

  38. Pingback: water ionizer plans

  39. Pingback: electrician tool bags australia

  40. Pingback: zakład szklarski piotrków trybunalski

  41. Pingback: house blue

  42. Pingback: electrician zurich

  43. Pingback: electrician jobs dublin va

  44. Pingback: HD Coloring Pages

  45. Pingback: ionizer loans

  46. Pingback: plan

  47. Pingback: water ionizer

  48. Pingback: loan payment plan

  49. Pingback: peco

  50. Pingback: alkaline water

  51. Pingback: shop car insurance

  52. Pingback: alkaline water

  53. Pingback: do you agree

  54. Pingback: water ionizer

  55. Pingback: here

  56. Pingback: material

  57. Pingback: budowa

  58. Pingback: tier2 junk

  59. Pingback: [Behind the Scenes] What Scientists at UCLA Are Saying About Meth Today | methrelief.org

Leave a Reply